For Treatment of Erectile Dysfunction: Start with tadalafil 5 mg and do not exceed a fix Erectile Dysfunction dose of tadalafil 10 mg every 72 hours. Seven days after PI initiation, restart tadalafil at 20 mg once daily and increase to tadalafil 40 mg once daily based on tolerability, sexual health. These benzodiazepines are metabolized via non-CYP pathways; thus, there is less interaction potential than with other benzodiazepines. Oral midazolam is contraindicated with PIs. Parenteral midazolam can be used with caution when given as a single dose in a monitored situation for procedural Sildenafil Citrate.